Search among available cruises
Filter Cruises
home ›

Cruises of Royal Caribbean in Panama

  • 2025
  • 2026
  • 2027
October 2025 November 2025 December 2025
January 2026 February 2026 March 2026 April 2026 May 2026 June 2026 July 2026 August 2026 September 2026 October 2026 November 2026 December 2026
January 2027 February 2027 March 2027 April 2027
78 cruises

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $1,060
price per person Taxes included
7 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Oct 11, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $977
price per person Taxes included
4 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Oct 18, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $1,060
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Oct 25, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $1,053
price per person Taxes included
4 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 1, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles

Colon Itinerary Caribbean
from $976
price per person Taxes included
6 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 8, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Kralendijk,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $910
price per person Taxes included
4 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 15, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $905
price per person Taxes included
8 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 22, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Oranjestad,
6. Willemstad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles

Colon Itinerary Caribbean
from $902
price per person Taxes included
6 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 29, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Kralendijk,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $895
price per person Taxes included
8 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Dec 6, 2025
Duration: 6 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $1,151
price per person Taxes included
6 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Dec 12, 2025
Duration: 8 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. navigation,
3. Cartagena De Indias,
4. navigation,
5. Kralendijk,
6. Oranjestad,
7. Willemstad,
8. navigation,
9. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $999
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Dec 20, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Willemstad,
6. Oranjestad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $1,273
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Dec 27, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Kralendijk,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $826
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Jan 3, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Kralendijk,
6. Oranjestad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $942
price per person Taxes included
4 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Jan 10, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. navigation,
6. Willemstad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $954
price per person Taxes included
7 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Jan 17, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Kralendijk,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $879
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Jan 24, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Kralendijk,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $878
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Jan 31, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Kralendijk,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $796
price per person Taxes included
4 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Feb 7, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Kralendijk,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $878
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Feb 14, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Oranjestad,
6. Willemstad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $761
price per person Taxes included
8 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Feb 21, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Kralendijk,
6. Oranjestad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $794
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Feb 28, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Kralendijk,
6. Oranjestad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $797
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Mar 7, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. navigation,
6. Willemstad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $794
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Mar 14, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $794
price per person Taxes included
5 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Mar 21, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Oranjestad,
6. Willemstad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $1,013
price per person Taxes included
5 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Mar 28, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Oranjestad,
6. Kralendijk,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $826
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Apr 4, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. navigation,
5. Oranjestad,
6. Willemstad,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $829
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Apr 11, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon
sold out

Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $989
price per person Taxes included
Serenade Of The Seas | Apr 18, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Central America: Panama, Costa Rica, Mexico, United States

Colon Itinerary Central America
from $1,087
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Apr 25, 2026
Duration: 10 nights
Departure from: Colon Landing: Los Angeles
Itinerary:
1. Colon,
2. navigation,
3. navigation,
4. Puntarenas,
5. navigation,
6. Huatulco,
7. navigation,
8. Puerto Vallarta,
9. navigation,
10. navigation,
11. Los Angeles

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $705
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Jewel Of The Seas | May 9, 2026
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon
78 cruises