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Departure calendar Panama

Choose your next cruise departing from the main ports in Panama, your new vacation by the sea is getting closer!

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Cruises in Panama

108 cruises
sold out

Panama, Spain, United States

Balboa Itinerary Mediterranean
from $4,010
price per person Taxes included
Silver Shadow | May 20, 2025
Duration: 7 nights
Departure from: Balboa Landing: Fort Lauderdale
Itinerary:
1. Balboa,
4. Cartagena ,
8. Fort Lauderdale

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $1,047
price per person Taxes included
5 reservations in 36 hours
Flash Sale Refundable Deposit Promo
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Serenade Of The Seas | Oct 11, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $966
price per person Taxes included
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Oct 18, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

Colon Itinerary Caribbean
from $1,047
price per person Taxes included
6 reservations in 48 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Oct 25, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Willemstad,
5. Oranjestad,
6. navigation,
7. navigation,
8. Colon

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

Colon Itinerary Caribbean
from $1,040
price per person Taxes included
6 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 1, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Oranjestad,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon

Central America: Panama, Costa Rica

Panama City Itinerary Central America
from $7,896
price per person Taxes included
See the cruise Book
Hanseatic Inspiration | Nov 8, 2025
Duration: 10 nights
Departure from: Panama City Landing: Colon
Itinerary:
1. Panama City,
3. Quepos,
4. navigation,
5. Puntarenas,
7. Playa Panama,
8. Panama Canal,
10. Colon,
11. Colon

Caribbean: Panama, Colombia, Netherlands Antilles

Colon Itinerary Caribbean
from $965
price per person Taxes included
8 reservations in 36 hours
Flash Sale Refundable Deposit Promo
See the cruise Book
Serenade Of The Seas | Nov 8, 2025
Duration: 7 nights
Departure from: Colon Landing: Colon
Itinerary:
1. Colon,
2. Cartagena De Indias,
3. navigation,
4. Kralendijk,
5. Willemstad,
6. navigation,
7. navigation,
8. Colon
108 cruises

All ships passing through Panama

Browse the list of ships with a scheduled stop in Panama, your next cruise is already here.

  • Featured ships
  • Other ships
Jewel Of The Seas Images of Jewel Of The Seas Serenade Of The Seas Images of Serenade Of The Seas Explora III Images of Explora III Azamara Quest Images of Azamara Quest Star Pride Images of Star Pride Wind Spirit Images of Wind Spirit Wind Star Images of Wind Star Insignia Images of Insignia
Marina Nautica Regatta Seabourn Encore Seven Seas Grandeur Seven Seas Splendor Le Champlain Hanseatic Inspiration

Panama: Ports of departure

Choose the port in Panama that is most convenient for you and get ready for your dream cruise to the most iconic destinations in the region.

  • Featured ports
  • Other ports
Balboa Images of Balboa Colon Images of Colon Panama City Images of Panama City