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Cruise from Santo Domingo

Caribbean Rhythms from Santo Domingo!

Embark on a vibrant Caribbean cruise from Santo Domingo, the historic capital of the Dominican Republic. As the oldest continuously inhabited European-established settlement in the Americas, this city offers an unparalleled blend of colonial charm and lively Caribbean culture. Explore its UNESCO-listed Colonial Zone before setting sail on a journey filled with sun-drenched beaches, rhythmic music, and unforgettable island discoveries.

28 cruises
Caribbean: Dominican Republic, Martinique, Guadeloupe, Saint Kitts and Nevis, Antigua and Barbuda, British Virgin Islands
Santo Domingo Itinerary Caribbean
from $726
price per person Taxes included
See the cruise Book Online Book Online
Costa Serena | Dec 6, 2027
Duration: 7 nights
Departure from: Santo Domingo Landing: Santo Domingo
Itinerary:
1. Santo Domingo,
2. navigation,
3. Fort de france,
4. Pointe à Pitre,
5. Basseterre,
6. Saint Johns,
7. Tortola Island,
8. Santo Domingo
Caribbean: Dominican Republic, Martinique, Guadeloupe, Antigua and Barbuda, Saint Kitts and Nevis, Sint Maarten
Santo Domingo Itinerary Caribbean
from $726
price per person Taxes included
See the cruise Book Online Book Online
Costa Serena | Dec 13, 2027
Duration: 7 nights
Departure from: Santo Domingo Landing: Santo Domingo
Itinerary:
1. Santo Domingo,
2. navigation,
3. Fort de france,
4. Pointe à Pitre,
5. Saint Johns,
6. Basseterre,
7. Philipsburg,
8. Santo Domingo
Caribbean: Dominican Republic, Antigua and Barbuda, Martinique, Guadeloupe, Saint Kitts and Nevis, British Virgin Islands
Santo Domingo Itinerary Caribbean
from $726
price per person Taxes included
See the cruise Book Online Book Online
Costa Serena | Jan 3, 2028
Duration: 7 nights
Departure from: Santo Domingo Landing: Santo Domingo
Itinerary:
1. Santo Domingo,
2. navigation,
3. Saint Johns,
4. Fort de france,
5. Pointe à Pitre,
6. Basseterre,
7. Tortola Island,
8. Santo Domingo
Caribbean: Dominican Republic, Antigua and Barbuda, Martinique, Guadeloupe, Saint Kitts and Nevis, British Virgin Islands
Santo Domingo Itinerary Caribbean
from $726
price per person Taxes included
See the cruise Book Online Book Online
Costa Serena | Jan 10, 2028
Duration: 7 nights
Departure from: Santo Domingo Landing: Santo Domingo
Itinerary:
1. Santo Domingo,
2. navigation,
3. Saint Johns,
4. Fort de france,
5. Pointe à Pitre,
6. Basseterre,
7. Tortola Island,
8. Santo Domingo
Caribbean: Dominican Republic, Antigua and Barbuda, Martinique, Guadeloupe, Saint Kitts and Nevis, British Virgin Islands
Santo Domingo Itinerary Caribbean
from $726
price per person Taxes included
See the cruise Book Online Book Online
Costa Serena | Feb 28, 2028
Duration: 7 nights
Departure from: Santo Domingo Landing: Santo Domingo
Itinerary:
1. Santo Domingo,
2. navigation,
3. Saint Johns,
4. Fort de france,
5. Pointe à Pitre,
6. Basseterre,
7. Tortola Island,
8. Santo Domingo
28 cruises

Departure calendar

Browse the catalog of all cruises departing from Santo Domingo now and find the one that suits your needs best.

  • 2027
  • 2028
November 2026 December 2026
January 2027 February 2027 March 2027 April 2027 May 2027 June 2027 July 2027 August 2027 September 2027 October 2027 November 2027 December 2027
January 2028 February 2028 March 2028

All ships departing from Santo Domingo

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Costa Favolosa Images of Costa Favolosa Costa Serena Images of Costa Serena