Departure calendar Panama City

Browse the catalog of all cruises departing from Panama City now and find the one that suits your needs best.

  • 2025
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  • 2027
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Cruises from Panama City

Panama City, the capital of Panama, is a vibrant, cosmopolitan metropolis where a rich history meets a dynamic modern culture. The city is a mix of old and new, historic districts perfectly coexist with modern infrastructure. On the one hand, visitors have the opportunity to visit many historical attractions. The best way to learn about the canal's history and operations is to visit the Miraflores Locks or, if you want to learn more about the history of the city, you should visit the districts of Casco Viejo or Panama Viejo.

2 cruises

Central America: Panama, Costa Rica

Panama City Itinerary Central America
from $7,990
price per person Taxes included
Hanseatic Inspiration | Nov 8, 2025
Duration: 10 nights
Departure from: Panama City Landing: Colon
Itinerary:
1. Panama City,
3. Quepos,
4. navigation,
5. Puntarenas,
7. Playa Panama,
8. Panama Canal,
10. Colon,
11. Colon

Central America: Panama, El Salvador, Guatemala, Mexico, United States

Panama City Itinerary Central America
from $6,686
price per person Taxes included
2 reservations in 72 hours
Explora III | Apr 22, 2027
Duration: 11 nights
Departure from: Panama City Landing: Los Angeles
Itinerary:
1. Panama City,
2. navigation,
3. navigation,
4. Acajutla,
5. Puerto Quetzal,
6. Ciudad Madero,
7. Huatulco,
8. navigation,
9. Puerto Vallarta,
10. navigation,
11. navigation,
12. Los Angeles
2 cruises

In Casco Viejo, a UNESCO World Heritage Site, you can see examples of colonial architecture, a vibrant nightlife, and cultural landmarks such as the Panama Cathedral and the Presidential Palace while Panama Viejo offers the opportunity to visit the ruins of the original city and it provides a glimpse into the early history of Panama. On the other hand, Panama City is currently known for its impressive skyline that reflect its status as a financial center. The modern culture of the city is mainly visible in the banking area and along one the city’s main streets, Calle 50, where large, shiny glass buildings line the streets.

All ships departing from Panama City

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