Search among available cruises
Filter Cruises
Home›All ports of departure›Porti in Panama›Panama City

Departure calendar Panama City

Browse the catalog of all cruises departing from Panama City now and find the one that suits your needs best.

  • 2024
  • 2025
  • 2026
  • 2027
December 2024
January 2025 February 2025 March 2025 April 2025 May 2025 June 2025 July 2025 August 2025 September 2025 October 2025 November 2025 December 2025
January 2026 February 2026 March 2026 April 2026 May 2026 June 2026 July 2026 August 2026 September 2026 October 2026 November 2026 December 2026
January 2027 February 2027 March 2027

Cruises from Panama City

Panama City, the capital of Panama, is a vibrant, cosmopolitan metropolis where a rich history meets a dynamic modern culture. The city is a mix of old and new, historic districts perfectly coexist with modern infrastructure. On the one hand, visitors have the opportunity to visit many historical attractions. The best way to learn about the canal's history and operations is to visit the Miraflores Locks or, if you want to learn more about the history of the city, you should visit the districts of Casco Viejo or Panama Viejo.

14 cruises

Caribbean: Panama, Costa Rica, Jamaica, Cayman Islands, Mexico, Bahamas, United States

favorite
Panama City Itinerary Caribbean
from $860.27
price per person Taxes included
4 reservations in 48 hours
See the cruise Book
Norwegian Gem | Dec 11, 2024
Duration: 9 nights
Departure from: Panama City Landing: Miami
Itinerary:
1. Panama City,
2. navigation,
3. Limón,
4. navigation,
5. Falmouth,
6. George Town,
7. Cozumel Island,
8. navigation,
9. Stirrup Cay,
10. Miami

Caribbean: Panama, Colombia, Jamaica, Cayman Islands, Honduras, Belize, Mexico, United States

favorite
Panama City Itinerary Caribbean
from $1,299.35
price per person Taxes included
2 reservations in 72 hours
See the cruise Book
Norwegian Jade | Jan 19, 2025
Duration: 10 nights
Departure from: Panama City Landing: Tampa
Itinerary:
1. Panama City,
2. navigation,
3. Cartagena De Indias,
4. navigation,
5. Falmouth,
6. George Town,
7. Roatan,
8. Harvest Cay,
9. Cozumel Island,
10. navigation,
11. Tampa

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles, Saint Kitts and Nevis, British Virgin Islands, Dominican Republic, United States

favorite
Panama City Itinerary Caribbean
from $1,584.25
price per person Taxes included
2 reservations in 72 hours
See the cruise Book
Norwegian Jade | Feb 9, 2025
Duration: 11 nights
Departure from: Panama City Landing: Miami
Itinerary:
1. Panama City,
2. navigation,
3. Cartagena De Indias,
4. navigation,
5. Oranjestad,
6. Willemstad,
7. navigation,
8. Basseterre,
9. Tortola Island,
10. San Felipe de Puerto Plata,
11. navigation,
12. Miami

Caribbean: Panama, Spain, Colombia, Aruba, Netherlands Antilles, Jamaica, Bahamas, United States

favorite
Panama City Itinerary Caribbean
from $3,115.98
price per person Taxes included
10 reservations in 36 hours
See the cruise Book
Sirena | Feb 18, 2025
Duration: 11 nights
Departure from: Panama City Landing: Miami
Itinerary:
1. Panama City,
2. navigation,
3. Panama City,
4. Cartagena ,
5. Santa Marta,
6. Oranjestad,
7. Willemstad,
8. Kralendijk,
9. navigation,
10. Port Antonio,
11. navigation,
12. Nassau,
13. Miami
sold out

Panama, Colombia, Jamaica, Cayman Islands, Mexico, Bahamas, United States

favorite
Panama City Itinerary Caribbean
from $1,106.07
price per person Taxes included
Norwegian Jade | Mar 4, 2025
Duration: 9 nights
Departure from: Panama City Landing: Port Canaveral
Itinerary:
1. Panama City,
2. navigation,
3. Cartagena De Indias,
4. navigation,
5. Ocho Rios,
6. George Town,
7. Cozumel Island,
8. navigation,
9. Stirrup Cay,
10. Port Canaveral
14 cruises

In Casco Viejo, a UNESCO World Heritage Site, you can see examples of colonial architecture, a vibrant nightlife, and cultural landmarks such as the Panama Cathedral and the Presidential Palace while Panama Viejo offers the opportunity to visit the ruins of the original city and it provides a glimpse into the early history of Panama. On the other hand, Panama City is currently known for its impressive skyline that reflect its status as a financial center. The modern culture of the city is mainly visible in the banking area and along one the city’s main streets, Calle 50, where large, shiny glass buildings line the streets.

All ships departing from Panama City

From the smallest and most intimate to the largest and most technological: find out which ships are departing from {port}.

  • Featured ships
Serenade Of The Seas Images of Serenade Of The Seas Norwegian Gem Images of Norwegian Gem Norwegian Jade Images of Norwegian Jade Insignia Images of Insignia Sirena Images of Sirena Seven Seas Grandeur Images of Seven Seas Grandeur